14-3-3η Protein Biomarker

Test Code: 143
Download File: RDL_RAdx3-TECHNOTE-9-6.pdf
CPT Code: 83520
Methodology: EIA
Specimen Requirements: 3mL (1 mL min) Serum or Plasma; Ambient, Refrigerated or Frozen

Stable 4 days ambient, 14 days refrigerated, 3 months frozen

Turn Around Time: 4-5 days
Special Instructions: None
Description: 14-3-3η is an isoform of a family of proteins involved in the regulation of biologic activity of intracellular proteins. The 14-3-3η protein is released into the blood during synovial inflammation and is associated with the upregulation of factors leading to joint damage. Recent studies have found that 14-3-3η can be useful in helping make a diagnosis in both early and established RA, in identifying RA patients seronegative for anti-CCP and RF, and for monitoring clinical response to treatment as well as the risk of radiographic progression. 14-3-3η has also been found to be predictive of erosive disease in Psoriatic Arthritis patients (PsA).